Molecular Genetic Methodologies for Pharmaceutical Sciences

(PHC 543)

January 8 - 12, 2001

Daily Schedule

 

Monday, 8 January

9:00

- 10:00 Introduction
10:00 - 11:30 Lab: Isolation of total RNA
11:30 - 12:30 Lunch
12:30 - 1:30 Lab: Gel electrophoresis of total RNA
1:30 - 2:30 Lecture:  Primer on nucleic acids and genomes
2:30 - 3:00 Break
3:00 - 4:00 Lecture: Primer on genetics
4:00 - 5:00 Discussion: Lab results

 

Tuesday, 9 January

9:00

- 10:00 Lab: cDNA synthesis
10:00 - 11:00 Lecture:  Enzymes in molecular biology
11:00 - 12:00 Lecture: Polymerase chain reaction I
12:00 - 1:00 Lunch
1:00 - 2:30 Lab: RT-PCR
2:30 - 3:30 Lecture:  Polymerase chain reaction II
3:30 - 4:00 Break
4:00 - 5:00 Lecture: Bioinformatics & Molecular Biology Databases

 

Wednesday, 10 January

9:00

- 9:30 Lab: Gel fractionation of PCR products
9:30 - 10:30 Lecture: Nucleic acid hybridization assays
10:30 - 11:30 Lab: RNA probe synthesis
11:30 - 12:00 Lab:  Analysis of PCR fragments
12:00 - 1:00 Lunch
1:00 - 2:00 Lab:  Pre-hybridization
2:00 - 3:00 Lab: Cloning of PCR products - ligation
3:00 - 3:30 Break
3:30 - 4:00 Lab:  Hybridization
4:00 - 5:00 Lab: Cloning of PCR products - transformation
 
Thursday, 11 January

9:00

- 11:00 Lab: Chemiluminescent detection
11:00 - 12:00 Lecture: Ligation reactions
12:00 - 1:00 Lunch
1:00 - 2:30 Lecture: Array analysis
2:30 - 3:00 Break
3:00 - 4:30 Lecture: Cloning strategies
4:30 - 5:00 Lab: Positive colony selection and setup of overnight cultures

Friday, 12 January

9:00

- 10:00 Lab: Mini-preparation of plasmid DNA
10:00 - 11:00 Lab: Restriction digestion and gel fractionation
11:00 - 12:00 Lab: Analysis of restriction digestions
12:00 - 1:00 Lunch
1:00 - 3:00 Discussion: Lab results
3:00 - 3:15 Workshop Conclusion and Evaluation