1996 Buffalo Pharmaceutics Symposium Program

1996 Buffalo Pharmaceutics Symposium

Strategies for Drug Development in the Next Decade:
Anticipating the Impacts of Combinatorial Chemistry and Pharmacoeconomics.

August 1-3, 1996

Preliminary Program

August 1: Reception 6:00 - 8:00 p.m., University Inn

August 2: Screening Room, Fine Arts Center, University at Buffalo

Session I: Combinatorial chemistry and its impact on pharmaceutical analysis-- Ho-Leung Fung, Chair

9:15 - 9:20 a.m.	*Welcome*
	Ho-Leung Fung University at Buffalo
9:20 - 10:10 a.m.	*Combinatorial Chemistry: what is it and where it is going?*
	Michael Pavia Sphinx Pharmaceuticals
10:10- 10:25 a.m.	*Break*
10:25 - 11:00 a.m	*Application of automated LC/MS in supporting drug discovery*
	Edward Kerns Bristol Myers Squibb
11:00 - 11:35 a.m	*The Use of LC/MS in the Clinical Development of Drugs*
	Mario Rocci Oneida Research
11:35 - noon	*Panel Discussion*

noon - 1 p.m. Lunch

1:00 - 2 p.m. Poster session

Session II: How should we screen for drug absorption?-- Robert M. Straubinger, Chair

2:00 - 2:35 p.m.	*Caco-2 cells: where are we now?*
	Saeho Chong Bristol Myers Squibb
2:35 - 3:10 p.m.	*Mechanism-based transport studies with Caco-2 cells: in vitro/in vivo considerations.*
	Philip Burton Pharmacia & Upjohn
3:10 - 3:25 p.m.	*Break*
3:25 - 4:00 p.m.	*Defining and overcoming problems in oral drug delivery.*
	Bruce Aungst DuPont Merck
4:00 - 4:35 p.m.	*Use of animal models in screening drug absorption.*
	Steven C. Sutton Pfizer Central Research
4:35 - 5 p.m.	*Panel Discussion*

Evening - Free Activity

August 3: Screening Room, Fine Arts Center, University at Buffalo

Session III: Strategies for Screening Drug Metabolism/Pharmacokinetics: Future Directions-- Marilyn Morris, Chair

9:00 - 9:35 a.m	*Evolving strategies of drug metabolism in support of drug discovery*
	Ronald E. White Bristol Myers Squibb
9:35 - 10:10 a.m	*In vitro approaches for prediction of drug disposition in human subjects*
	James G. Baxter Pfizer
10:10- 10:25 a.m.	*Break*
10:25 - 11:00 a.m	*Prediction of human absorption and metabolism of Indinavir: In vitro-in vivo approaches.*
	Juinn Lin Merck & Co
11:00 - 11:35 a.m	*In vivo and in vitro catalytic probes for CYP3A*
	Danny Shen University of Washington
11:35 - noon	*Panel Discussion*

noon - 1 p.m. Lunch

1:00 - 2 p.m. Poster session

Session IV: Clinical PK/PD Study Design and Pharmacoeconomics-- Gerhard Levy, Chair

2:00 - 2:35 p.m.	Optimum design of population PK/PD studies: How to do things right the first time.
	Alan Forrest University at Buffalo and the Millard Fillmore Hospital
2:35 - 3:10 p.m.	*What does an HMO and PBM want to know about the pharmacoeconomics of a drug? (title tentative)*
	Albert Wertheimer First Health Services, Inc
3:10 - 3:25 p.m.	*Break*
3:25 - 4:00 p.m.	*Important economic outcome measures in the decision to market a drug for hospital use.*
	Joseph Paladino Millard Fillmore Suburban Hospital
4:00 - 4:35 p.m.	*Pharmacoeconomics -- a perspective from the pharmaceutical industry.*
	(tentative)
4:35 - 5 p.m.	*Panel Discussion*

6:00 p.m. Picnic

August 4: Departure

For more information:

Ho-Leung Fung: hlfung@acsu.buffalo.edu