Department of Pharmaceutical Sciences SUNY/Buffalo Circular Dichroism Facility

To schedule time and training on this CD instrument, contact Dr. Vandana Iyer at (716) 645-2842 x221 or email at vb4@buffalo.edu

The CD facility also has a JASCO J500C instrument equipped with analog data output and a temperature-controlled sample compartment to enable temperature-dependent studies (such as folding/unfolding of protein pharmaceuticals). Hardware modifications allow data acquisition down to 187 nm. Ancillary spectral processing software capabilities of the facility include the analysis of far UV CD data to obtain the secondary structural content of proteins and peptide pharmaceuticals.

The facility serves a variety of research projects involving protein structure, drug-protein interactions, and pharmaceutical formulation.

The facility is available to the campus and local research community on a recharge basis. Both an instrument operator and scientific consulting expertise are available on a cost-recovery basis. Research groups having a major and ongoing need for CD data acquisition may elect to receive training and provide their own qualified operator.

Selected research, publications

Here are some of the research activities at this facility:

• Research
• Publications

Instructional activities

• PHC 540: Contemporary Methods in Pharmaceutical Research1: Biophysical approaches in pharmaceutical research: pharmaceutical biotechnology.

Links to information about CD

Here are some starting points for access to on-line information about CD and related aspects of Structural Biology:

• The UMDNJ Circular Dichroism Facility
  Links to tutorials on CD, analysis software and other sites Circular Dichroism Facility
• The UNC Macromolecular Interactions Facility
  • CD Facility
    • Sample Preparation
• CCD Deconvlution, links to other resources and software
• Instruments
  • Aviv Instruments
  • Jasco Instruments
  • OLIS Instruments
    • CD Instruments

For further information about using this facility:

Other faculty overseeing facility:

Dr. Sathy Balu-Iyer Department of Pharmaceutical Sciences (716) 645-2844 x245 svb@acsu.buffalo.edu	Dr. RM Straubinger Department of Pharmaceutical Sciences (716) 645-2844 x243 rms@acsu.buffalo.edu

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