Department of Pharmaceutical Sciences

SUNY/Buffalo

Circular Dichroism Facility

Through a grant from the National Institutes of Health, Division of Research Resources, our faciltiy has a state-of-the-art CD instrument, operated as a shared facility. This instrument is a JASCO J-715, with the capability for simultaneous CD/fluorescence data acquisition, 4-channel stopped flow, titrator, fast-responding peltier-effect temperature control, and full computer control of experimental setup and data acquisition.

To schedule time and training on this CD instrument, contact Dr. Vandana Iyer at (716) 645-2842 x221 or email at vb4@buffalo.edu

The CD facility also has a JASCO J500C instrument equipped with analog data output and a temperature-controlled sample compartment to enable temperature-dependent studies (such as folding/unfolding of protein pharmaceuticals). Hardware modifications allow data acquisition down to 187 nm. Ancillary spectral processing software capabilities of the facility include the analysis of far UV CD data to obtain the secondary structural content of proteins and peptide pharmaceuticals.

The facility serves a variety of research projects involving protein structure, drug-protein interactions, and pharmaceutical formulation.

The facility is available to the campus and local research community on a recharge basis. Both an instrument operator and scientific consulting expertise are available on a cost-recovery basis. Research groups having a major and ongoing need for CD data acquisition may elect to receive training and provide their own qualified operator.


Selected research, publications

Here are some of the research activities at this facility:

Instructional activities

Links to information about CD

Here are some starting points for access to on-line information about CD and related aspects of Structural Biology:


For further information about using this facility:

Dr. Vandana Iyer
Department of Pharmaceutical Sciences
(716) 645-2842 x221
vb4@buffalo.edu

Other faculty overseeing facility:
Dr. Sathy Balu-Iyer
Department of Pharmaceutical Sciences
(716) 645-2844 x245
svb@acsu.buffalo.edu
Dr. RM Straubinger
Department of Pharmaceutical Sciences
(716) 645-2844 x243
rms@acsu.buffalo.edu

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