Ninth Buffalo Pharmaceutics Symposium

Theme: Hot topics in pharmaceutics: N-in-1 pharmacokinetics and pharmaceutical transporters


August 2-4, 1998


Preliminary Program

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August 2 (Sunday): 6:30pm Reception & Dinner at:

University Inn, 2401 N. Forest Road, Amherst NY

Dr. Levy's Birthday celebration


August 3 (Monday): Cooke-Hochstetter Hall

Session I: N-in-1 pharmacokinetics: Predictability and Limitation

9:00 - 9:40 a.m. Minimalistic pharmacokinetics

William Jusko
University at Buffalo
9:40 - 10:20 a.m. Shaken, not stirred: Approaches and pitfalls of cocktail approaches to drug disposition science
Scott Obach
Pfizer
10:20 - 10:40 a.m. Coffee Break
10:40 - 11:10 a.m. N-in-1 mixture dosing: Its application and limitation
Frank Lee
DuPont-Merck
11:10 - 11:40 a.m. Cassette dosing and cassette analysis: Meeting the high- throughput challenge
Lloyd Frick
Glaxo Wellcome
11:40 - 12:00 p.m. Panel Discussion

12:00 - 1:15pm Lunch at Pistachio's, Student Union

Session II: General PK/PD/Transport

1:20 -1:40 p.m. PK/PD analysis guided drug discovery and development: Take Ro 25-8310, a long-acting IFN as an example
Rick Xu
Roche
1:40 - 2:00 p.m. New mathematical concepts in pharmacodynamic
Wojciech Krzyzanski
University at Buffalo, Post-doc
2:00 - 2:20 p.m. Modeling, forecasting, and simulation: Information propagation in drug development
Jeff Wald
Pharsight Corporation
2:20 - 2:40 p.m. Relationship between kinetic parameters of mechanism- based enzyme inactivation and inhibitory potency: Implications for design and development
Tristan Maurer
University at Buffalo, Grad. Student
2:40 - 3:00 p.m. Changes in the pharmacokinetics/pharmacodynamics of ciprofloxacin
Iron Ron Li
The Chinese University of Hong Kong
3:00 - 3:20 p.m. Coffee Break
3:20 - 3:40 p.m. Pharmacodynamics of paclitaxel: Investigation of antitumor efficacy by the duration of drug exposure
Gerald Fetterly
University at Buffalo, Grad. Student
3:40 - 4:00 p.m. Pharmacokinetics and dynamics of clevedipine - an ultra- short acting dihydropyridine calcium antagonist
Carl G Regärdh
Astra Hässle
4:00 - 4:20 p.m. PK/PD interactions of prednisolone and IL-10
Abhijit Chakrabourty
University at Buffalo, Grad. Student
4:20 - 4:40 p.m. Pharmaco-/toxico-dynamic of drug action: Signaling events in cell survival and cell death
Ah-Ng Tony Kong
University of Illinois
4:40 - 5:00 p.m. Model of maturation and growth influence on glomerular filtration rate and its application to dosing regimen design in children
William Hayton
Ohio State University

6:00pm Picnic at the Pendleton House/Rookies Restaurant: 6886 S. Transit Road, Lockport


August 4 (Tuesday): Cooke-Hochstetter Hall

Session III: Transporters involved in ADME

9:00 - 9:35 a.m. The multiplicity of intestinal absorption mechanisms and impact on oral bioavailability
Patrick Sinko
Rutgers University
9:35 - 10:10 a.m. Physiology and drug transport across the blood-brain barrier: Challenges for drug development
Joe Polli
Glaxo Wellcome
10:10 - 10:30 a.m. Coffee Break
10:30 - 11:05 a.m. Hepatic transport of anions
K. Sandy Pang
University of Toronto
11:05 - 11:40 a.m. Hepatic and intestinal transport of organic cations
Marilyn Morris
University at Buffalo
11:40 - 12:00 p.m. Panel Discussion

12:00 - 1:15 p.m. Lunch at Bert's, Tablert Hall

Session IV: General PK/PD/Transport

1:20 -1:40 p.m. Drug transport in epithelial tissue: Enhancement by drug-induced apoptosis
Guill Wientjes
Ohio State University
1:40 - 2:00 p.m. Physiological regulation of renal sulfate transport
Hwa-Jeong Lee
University at Buffalo, Grad. Student
2:00 - 2:20 p.m. Avitriptan: Effects of renal and hepatic impairment on pharmacokinetics
Dan Salazar
Bristol-Myers Squibb
2:20 - 2:40 p.m. Nitric oxide in intestinal ischemia/reperfusion injury
Ashish Khanna
University at Buffalo, Grad. Student
2:40 - 3:00 p.m. Nitrate-induced vascular tolerance and nitric oxide redox related species
Mohammad Tabrizi-Fard
University at Buffalo, Post-doc
3:00 - 3:20 p.m. Coffee Break
3:20 - 3:40 p.m. Opioids as a potential new treatment for arthritis: Mechanisms of action
Judy Walker
University of NSW
3:40 - 4:00 p.m. CNS stimulatory effects of gallamine and other neuromuscular blockers
Iqbal Ramzan
University of Sydney
4:00 - 4:20 p.m. Assessment of Organic Cation Transport at the Blood-Brain Barrier with the IN Situ Brain Perfusion Technique
Kelly M. Mahar
University at Buffalo, Grad. Student


4:20pm Departure


For more information:

Elizabeth Rugg: Rugg@acsu.buffalo.edu

Click here for a registration form!