COURSE OUTLINE

In recent years significant progress has been made in the area of pharmacodynamics. On the basis of diverse pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of drug effects under physiological and pathological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, summarizing extensive data, finding optimal dosing regimens, and in making predictions under new circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in drug development.

This course will deal with the theoretical aspects and with the applications of simultaneous pharmacokinetic/pharmacodynamic modeling. Subjects that will be discussed include:

• Basic pharmacodynamic theory: receptor binding, post-receptor events, concentration-effect-time relationships;
• Pharmacokinetic complexities: e.g. the role of distribution, metabolites, enantiomers, protein binding, the implications for the design of in vivo pharmacodynamic investigations;
• Effect compartment modeling: parametric, semi-parametric and non-parametric approaches; biophase kinetics;
• Physiological pharmacokinetic-pharmacodynamic modeling: e.g. indirect response models, chemotherapeutic effects;
• Pharmacodynamic drug-drug interactions: isobolograms, competitive and non-competitive interactions;
• Functional tolerance development: inhibitory metabolite models, physiological feedback models, indirect models;
• Population pharmacodynamics: application of NONMEM in pharmacodynamics;
• Specific drug applications: CNS active agents, cardiovascular agents, corticosteroids, anticoagulants, antibiotics;
• Special topics:: Transduction, circadian rhythms, clinical trials simulation.

More Information:

COURSE DIRECTION

COURSE PROGRAM

REGISTRATION INFORMATION

For more information:

PK/PD MODELING,
Department of Pharmaceutics, School of Pharmacy,
State University of NY at Buffalo,
519 Hochstetter Hall, Buffalo, NY 14260, U.S.A.,
phone: 716 645 2855, ext. 224; fax: 716 645 3693.
email: wjjusko@acsu.buffalo.edu

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