Dr. Jusko (wjjusko@acsu.buffalo.edu) is Professor of Pharmaceutics at the School of Pharmacy of the State University of New York at Buffalo, U.S.A. As Director of the Pharmacoimmunodynamics Laboratory, Dr. Jusko supervises a research program on the pharmacokinetics and pharmacodynamics of immunosuppressive drugs such as corticosteroids, tacrolimus and sirolimus. Over the past 30 years, his research interests have also involved clinical, basic, and theoretical aspects of diverse drugs such as cardiac agents, antibiotics, antidepressants, theophylline, as well as effects of tobacco smoking, oral contraceptives, obesity, and reversible metabolism. He has authored over 400 publications and consults for the FDA, NIH, and pharmaceutical industry.
Dr. Mandema is currently Vice-President, Scientific Affairs, at Pharsight Corporation, Palo Alto, CA. He was previously at ALZA Corporation and Assistant Professor in the Department of Anesthesia, Stanford University School of Medicine. From 1987-1991 he was with the Center for Bio-Pharmaceutical Sciences, the Netherlands and from 1991-1992 with Dr. L.B. Sheiner at the University of California at San Francisco. Dr. Mandema has extensive experience with pharmacokinetic-pharmacodynamic modeling (in particular of CNS active, analgesic, and anesthetic drugs) population analysis (NONMEM), and clinical trials simulation.
Dr. Danhof is Professor and Head, Division of Pharmacology at the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, the Netherlands and Adjunct Professor of Pharmaceutics, State University of New York at Buffalo. Dr. Danhof supervises research on pharmacokinetics and pharmacodynamics. His research projects include the pre-clinical and clinical pharmacodynamics of CNS active drugs (hypnotics, sedatives, anti-epileptics, opiates and anti-Parkinson drugs), cardiovascular drugs (calcium antagonists, adenosine receptor agonists and antagonists) and anticoagulants (heparinoids). He is editor of "The In Vivo Study of Drug Action-Concepts and Applications of Kinetic-Dynamic Modeling".
For more information:
PK/PD MODELING
Department of Pharmaceutics, School of Pharmacy,
State University of NY at Buffalo,
519 Hochstetter Hall,
Buffalo, NY 14260, U.S.A.,
phone: 716 645 2855, ext. 224; fax: 716 645 3693.
email: wjjusko@acsu.buffalo.edu